Medicinal Potential of Flavonoids Extracted from The Leaves of Lippia multifora Moldenke: Review

Authors

  • Ortalie Jeancine Ouboura Moussavou

    Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

  • Archange Michel Emmanuel Mboungou Malonga

    Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo and Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, Republic of Congo

  • Landry Martial Miguel

    Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo and Denis SASSOU NGUESSO University, Kintélé, Republic of Congo

  • Berthrand Stéphane Wossolo Lingomo

    Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, Republic of Congo and Denis SASSOU NGUESSO University, Kintélé, Republic of Congo

  • Donatien Moukassa

    Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

  • Ange Antoine Abena

    Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo and Denis SASSOU NGUESSO University, Kintélé, Republic of Congo

How to Cite

Moussavou , O. J. O., Malonga , A. M. E. M., Miguel , L. M., Lingomo , B. S. W., Moukassa, D., & Abena , A. A. (2025). Medicinal Potential of Flavonoids Extracted from The Leaves of Lippia multifora Moldenke: Review. International Journal of Pharmacology and Toxicology, 13(2), 1-8. https://doi.org/10.14419/cagkqv46

Received date: June 19, 2025

Published date: June 19, 2025

DOI:

https://doi.org/10.14419/cagkqv46

Keywords:

Lippia multiflora, Flavonoids, Leaves, Medicinal potential

Abstract

Flavonoids are natural pigments found throughout the plant kingdom. They are present in certain fruits, vegetables, drinks, plant-based foods, and medicinal plants. They form a large family of several natural compounds. They include flavanols, flavanones, isoflavones, flavonols, flavones, and anthocyanins. The organoleptic properties and therapeutic effects of flavonoids extracted from the leaves of Lippia multifora Moldenke have been the subject of numerous studies. Flavonoids extracted from Lippia multifora Moldenke leaves are claimed to be antioxidant, anti-allergic, anti-inflammatory, antimicrobial, and anti-carcinogenic. They are used in a wide range of sectors, including food processing, cosmetology, and the pharmaceutical industry.

References

  1. M.E. Pascual, K. Slowing, E. Carretero, D. Sa'nchez Mata, A. Villar. Lippia: traditional uses, chemistry and pharmacology: a review. Journal of Ethnopharmacology 76 (2001) 201-214
  2. A.A. Abena, A.W. Etou Ossibi, Gouolally Tsiba, N. Okemy Andissa, J.M. Ouamba. Monographic study of Lippia multiflora Moldenke (Verbena-ceae). Phytotherapy. 2017 ;15(1) :27-32. doi :10.1007/s10298-016-1025-8
  3. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal. 2013 Dec 29; 2013:162750. doi: 10.1155/2013/162750. PMID: 24470791; PMCID: PMC3891543.
  4. Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016 Dec 29;5:e47. doi: 10.1017/jns.2016.41. PMID: 28620474; PMCID: PMC5465813.
  5. Hondi-Assah, T., Abena, A.A., Kokolo, J., Badila, C., & Diatewa, M.B. (2003). Hepatoprotective effects of Lippia multiflora and a Congolese phytomedicine: Tetra®. Sozial-und Praventivmedizin, 1, 135-140.
  6. Constantin M. Dabire, Remy K. Bationo, Adama Hema, Roger C. H. Nebie, Eloi Pale, S.P. Dhanabal and Mouhoussine Nacro. Total phenolics con-tent, flavonoids profiling and antioxidant activity of Lippia multiflora leaves extracts from Burkina Faso. Asian Journal of Plant Science and Re-search, 2015. 5(5): 28 - 33.
  7. Moldenke, H.N. (1980) Phytologia Memoirs II. A Sixth Summary of the Verbenaceae, Avicenniaceae, Stilbaceae, Chloanthaceae, Symphoremaceae, Nyctanthaceae and Eriocaulaceae of the World as to Valid Taxa, Geographic Distribution and Synonymy. U.S.A.
  8. Jigam AA, Akanya HO, Ogbadoyi EO, Dauda BEN, Egwim CE. In vivo antiplasmodi-al, analgesic and anti-inflammatory activities of the leaf ex-tract of Lippia multi¬flora mold. J Med Plants Res.2009 ;3(3): 148-154.
  9. C.A. Masengo, K.N. Ngbolua D. Ipepe, B.M. Mbembo, R.D. Djolu, C.L. Inkoto, D.D. Tshilanda, D.S.T. Tshibangu, G.B. Ilumbe, P.T. Mpiana. Socio-economic survey and antisickling activity of Gambia tea (Lippia multiflora Moldenke, Verbenaceae) in Western Democratic Republic of Congo. Revue Congolaise des Sciences & Technologies, 2022, Vol. 1(1): 24-34
  10. Abena AA, Diatewa M, Gakosso G, Gbeassor M, Hondi-Assah T, Ouamba JM. Analgesic, antipyretic and anti-inflammatory effects of essential oil of Lippia multiflora. Fitoterapia. 2003 Apr;74(3):231-6. doi: 10.1016/s0367-326x (03)00029-7.
  11. Landry Martial Miguel, Ortalie Jeancine Ouboura Moussavou, Choupette Ravelle Dobhat-Doukakini, Childérick Lékana, Archange Michel Em-manuel Mboungou Malonga, Didier Gesril Njilo Tchatchouang, Ruphin Bertrand Bolanga, Etienne Mokondjimobe, Gouollaly Tsiba, Donatien Moukassa and Ange Antoine Abena. Phytochemical analysis and in vitro evaluation of antioxidant and anticoagulant activities of Lippia multiflora Moldenke leaves. World Journal of Pharmaceutical and Life Sciences, 2022, 8(9) : 10-18
  12. Gouollaly T. 2010. Phytochemical study and evaluation of antifungal, anticancer and antioxidant activities of domestic lippia multiflora moldenke extracts. Thèse de doctorat Unique, Université Marien Ngouabi, Brazzaville, 219 P.
  13. Karim Tuo. In vitro phytochemical screening, antioxidant and antiplasmodial activity of five plants traditionally used in Côte d'Ivoire against malar-ia. Sciences du Vi-vant [q-bio]. Université Félix Houphouet-Boigny de Cocody, Abidjan, 2015. French. Tel-03069680
  14. Etou-Ossibi, AW, Dimo, T., Elion-Itou, RDG, Nsondé-Ntandou, GF, Nzonzi, J., Bilanda, DC & Abeena, AA. Effects of Lippia multiflora Mold-enke aqueous extract on DOCA salt-induced hypertension in rats. Phytotherapy, 2012, 10, p. 363-368.
  15. Ossibi, AE, Itou, RDGE, Nzonzi, J., Ntandou, GN, Dimo, T., Ouamba, JM and Abena, AA. Effects of aqueous extract of Lippia multiflora Mold-enke (Verbenaceae) on blood pressure, heart rate and electrocardiogram waves in normotensive rats. African Pharmacopoeia and Traditional Medi-cine, 2014, vol. 17, n°1.
  16. Adjanohoun, E., V. Adjakidje, M.R.A. Ahyi, K. Akpagana, P. Chibon, A. El - Hadji, J. Eyme, M. Garba, J. - N. Gassita, M. Gbeassor, E. Goudote, S. Guinko, K. - K. Hodouto, P. Houngnon, A. Keita, Y. Keoula, W. P. Kluga - Ocloo, I. Lo, K. M. Siamevi, K. K. Taffame. Contribution aux études ethnobotaniques et floristiques au Togo. Agence de coopération culturelle et technique, (A.C.C.T.), Paris, 671 p., (1986) From the PHAR-MEL 2 database (ref. HP 10)
  17. Adomou A.C., H. Yedomonhan, B. Djossa, S. I. Legba, M. Oumorou, A. Akoegninou. Etude Ethnobotanique des plantes médicinales vendues dans le marché d'Abomey-Calavi au Bénin Int. J. Biol. Chem. Sci, 2012, 6(2): 745-772
  18. Pousset, J.-L. Plantes médicinales africaines. Practical use. Agence de coopération culturelle et technique, (A.C.C.T.), Paris, 156 p., (1989)
  19. Asase, A., G. A. Akwetey, D. G. Achel. Ethnopharmacological use of herbal remedies for the treatment of malaria in the Dangme West District of Ghana Journal of Ethnopharmacology, 2010, 129: 367- 376
  20. Olowokudejo J. D., A. B. Kadiri, V.A. Travih. An Ethnobotanical Survey of Herbal Markets and Medicinal Plants in Lagos State of Nigeria Eth-nobotanical Leaflets, 2008, 12: pp 851-65. http://www.ethnoleaflets.com/leaflets/lagos.htm
  21. Diafouka, A. J. P. Analyse des usages des plantes médicinales dans 4 régions de Congo-Brazzaville. Thèse de doctorat, Université libre de Bruxelles, Faculté des Sciences, Laboratoire de Botanique Systématique et de Phytosociologie, 431 p., (1997).
  22. Konda ku Mbuta, Kabakura Mwima, Mbembe Bitengeli, Itufa Y'okolo, Mahuku Kavuna, Mafuta Mandanga, Mpoyi, Kalambayi, Ndemankeni Izamajole, Kadima Kazembe, Kelela Booto, Ngiuvu Vasaki, Bongombola Mwabonsika, Dumu Lody & Paul Latham. Traditional medicinal plants. Province de l'Equateur - R.D. Congo, Kinshasa 2012 (419 p.) Institut de Recherche en Sciences de la Santé (I.R.S.S.) in Kinshasa. ISBN 9780955420856
  23. Bossard, E. Traditional medicine in central and western Angola. Ministério da ciênciae da tecnologia. Instituto de investigaçâo cientifica tropical. Lisboa - p. 531 (1996)
  24. Ameyaw, Yaw (2009). A growth regulator for the propagation of Lippia multiflora Moldenke, a herbal for the management of mild hypertension in Ghana. Journal of Medicinal Plants Research. 3. 681-685.
  25. Ossibi, AE, Itou, RE, Morabandza, CJ, Ntandou, GN, Nzonzi, J., Ouamba, JM and Abena, AA (2016). Effects of hydroethanol extract of Lippia multiflora Moldenke on isolated toad heart. International Journal of Biological and Chemical Sciences, 2016, 10 (6): 2617-2636.
  26. Koïta, K & Baissac, Yves & Sanon, Elise & Campa, Claudine & Sankara, P. (2017). Phe-nolics from Lippia multiflora Moldenke as potential bioac-tive agents against peanut patho-gens. Agricultural Science Research Journal. 7. 267-276.
  27. Bassoueka, D. J., Loufoua, B. A. E., Etou-Ossibi, A. W., Nsondé-Ntandou, G. F., Ondelé, R., Elion-Itou, R. D. G., & Abena, A. A. (2015). Phyto-chemical, pharmacological and ethnobotany study of some Congolese plants with potential anticonvulsant. Phytotherapy, 5 (13): 298-305. https://doi.org/10.1007/s10298-015-0979-2
  28. Kanko, C., Koukoua, G., N'Guessan, Y. T., Fournier, J., Pradère, J.-P., & Toupet, L. (2004). Contribution to the phytochemical study of Lippia multiflora (Verbenaceae). Comptes Rendus. Chimie, 7(10-11), 1029-1032. https://doi.org/10.1016/j.crci.2003.12.028
  29. Lêniféré Chantal SORO, Mohamed Anderson YEO, Armand Kouassi Kouakou KOU-ADIO and Anin Louise OCHO-ANIN ATCHIBRI. Nutri-tional valorization of Côte d'Ivoire Savannah tea plant leaves. International Journal of Agricultural Policy and Research, 2021, Vol.9 (6), pp. 145-152. https://doi.org/10.15739/IJAPR.21.016
  30. C.A. MASENGO, G.N. BONGO, B. ROBIJAONA, G.B. ILUMBE, J-P. NGBOLUA KOTO-TE-NYIWA, P.T. MPIANA. Étude ethnobota-nique quantitative et valeur sociocultu-relle de Lippia multiflora Moldenke (Verbenaceae) à Kinshasa, République Démocratique du Congo. Revue Marocaine des Sciences Agronomiques et Vétérinaires. (2021) 9(1): 93-101
  31. Tzanova, Milena, Vasil Atanasov, Zvezdelina Yaneva, Donika Ivanova and Toncho Di-nev. 2020. “Selectivity of current flavonoid extraction techniques from plant materials” Pro-cess 8, no. 10: 1222. https://doi.org/10.3390/pr8101222
  32. Isorez, G., 2007. Contribution à la chimie des flavonoïdes: Accès à des analogues de pig-ments du vin rouge. Thèse de Doctorat Ph. D, Université Louis Pasteur - Strasbourg I; p 218.
  33. K. Ghedira. Les flavonoïdes: Structure, propriétés biologiques, rôle prophylactique et em-plois en thérapeutique. Phytothérapie, 2005, vol. 3, n 4, p. 162-169. © Springer 2005. https://doi.org/10.1007/s10298-005-0096-8
  34. Khan H, Jawad M, Kamal MA, Baldi A, Xiao J, Nabavi SM, Daglia M. Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future. Food Chem Toxicol. 2018; 119:355-367. doi: 10.1016/j.fct.2018.02.014.
  35. Elise Emeraux. Propriétés biologiques des flavonoïdes: étude bibliographique et évalua-tion de l'activité antioxydante. Sciences pharmaceutiques. 2019. hal-03297878
  36. Shyam Sunder Rabidas, Chandra Prakash, Jyoti Tyagi et JyotiSuryavanshi. A Compre-hensive Review on Anti-Inflammatory Response of Flavo-noids in Experimentally Induced Epi-leptic Seizures. Brain Sciences,vol, 2023, 13(1): 102
  37. Jameel M. Al-Khayri, Gandasi Ravikumar Sahana, Praveen Nagella et Biljo V. Joseph. Flavonoids as Potential Anti-Inflammatory Molecules: ARe-view. Molecules, 2022, 27(9): p. 2901 (https://dx.doi.org/10.3390/molecules27092901)
  38. Kaihui Lu et Yew Mun Yip. Therapeutic Potential of Bioactive Flavonoids from Citrus Fruit Peels toward Obesity and Diabetes Mellitus. Future Pharmacology, 2023, 3(1): p. 14-37 (https://dx.doi.org/10.3390/futurepharmacol3010002)
  39. Adrien T.uwisana Masunda, Clément Liyongo Inkoto, Colette Ashande Masengo, Sylvie Bolisomi Bongili, Jean-Pierre Kanza Basilua, Emanuel Moke Legbiye, Koto-Te-Nyiwa Ngbolua, Pius Tshimankinda Mpiana. Traditional uses, physical properties, phytochemistry and bioactivity of Lip-pia multiflora Moldenke (Verbenaceae): A Mini-review3. Discov-ery Phyto-medicine 2020, 7(1): 19-26
  40. Dossa Clément GANDONOU, Hyacinthe AHISSOU, Jean-MarieTOKOUDAGBA and Christian DANSOU. Ethnobotanical, phytochemical and toxicity analysis of a Beninese anti-hypertensive plant: Lippia multiflora. Int. J. Biol. Chem. Sci.2017, 11(4): 1816-1828.
  41. Clément D. Gandonou, Jean-Marie Tokoudagba, Alban G. Houngbèmè, Marthe D. Cho-daton and Hyacinthe Ahissou. Antiradical activity and de-termination of phenolic compounds in extracts of Lippia multiflora (Verbenaceae): a plant traditionally used against arterial hyperten-sion in Benin. International Journal of Current Research, 2018, 10(10): pp.74039-74043. https://doi.org/10.24941/ijcr. 32498.10.2018
  42. [42] N'Dri Koffi, Emmanuel, Yeboue Koffi François Kouakou, Bleouh Yves Nyamien, Roland Kouadoueu Deli, and Louise Atchibri Anin. 2021. Optimization of total flavonoid extraction and antioxidant activity from Lippia multiflora Moldenke (Verbenaceae) leaves using an exper-imental design. Journal of Advances in Medical and Pharmaceutical Sciences 23 (8) :1-11. https://doi.org/10.9734/jamps/2021/v23i830250.
  43. [43] Fako, Kane & Yves, Djina & Siméon, Brou & jean, Gonnety. 2021. Biochemical composi-tion and sensory characteristics of leaf infusions of two morphotypes of Lippia multiflora (ver-benaceae) grown in Côte d'Ivoire. Journal of Applied Biosciences. 158. 16332-16339. 10.35759/JABs.158.7.
  44. Joseph Ngaibi, Germain Sotoing Taiwe, Jacqueline Stephanie Kameni Njapdounke, Bi-gued, Yvette Nguezeye, Neteydji Sidiki and Elisabeth Ngo Bum. Potential of an aqueous ex-tract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotonergic transmission. GSC Biological and Pharmaceutical Sciences, 2021, 14(03), 277-289.
  45. C.A Massengo, K. N. Ngbolua, S.L. Omeonga, N.P. Nzuzi, G.B. Ilumbe, P.T. Mpiana. Phytochemical study and evaluation of the antiradical, anti-inflammatory; anti-sickle cell and cytotoxic activity of Lippia multiflora Moldenke (Verbenaceae) leaves. Rev.Mar. Sci. Agron. Vet. 2023, 11(3), 303-312.

Downloads

How to Cite

Moussavou , O. J. O., Malonga , A. M. E. M., Miguel , L. M., Lingomo , B. S. W., Moukassa, D., & Abena , A. A. (2025). Medicinal Potential of Flavonoids Extracted from The Leaves of Lippia multifora Moldenke: Review. International Journal of Pharmacology and Toxicology, 13(2), 1-8. https://doi.org/10.14419/cagkqv46

Received date: June 19, 2025

Published date: June 19, 2025